The antitumor drug gimatecan is available as nearly pure (S)-enantiomer. Neither pure (R) enantiomer nor a racemic (equal) mixture of the two enantiomers are available. To measure small quantities of (R)-enantiomer in nearly pure (S)-gimatecan, a preparation
(a) Explain the appearance of the upper chromatograms. Dashed lines are position markers, not part of the chromatogram. What would the chromatogram of pure (R)-gimatecan look like on the same two stationary phases?
(b) Explain the appearance of the two lower chromatograms and why it can be concluded that the gimatecan contained 0.03% of the (R)-enantiomer. Why is the (R)-enantiomer not observed with the (R,R)-stationary phase?
(c) Find the adjusted relative retention (?) and unadjusted relative retention (?) for the two enantiomers on the (S,S)-stationary phase.
This question was answered on: Jul 11, 2017
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